Loading ...Mechanism
Asperger syndrome appears to result from developmental factors that affect many or all functional brain systems, as opposed to localized effects.[29] Although the specific underpinnings of AS or factors that distinguish it from other ASDs are unknown, and no clear pathology common to individuals with AS has emerged,[1] it is still possible that AS’s mechanism is separate from other ASD.[30] Neuroanatomical studies and the associations with teratogens strongly suggest that the mechanism includes alteration of brain development soon after conception.[27] Abnormal migration of embryonic cells during fetal development may affect the final structure and connectivity of the brain, resulting in alterations in the neural circuits that control thought and behavior.[31] Several theories of mechanism are available; none are likely to be complete explanations.[32]
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